• Applications for protein switches are numerous In diagnostic

  2023-12-18

  

  Applications for protein switches are numerous. In diagnostics, protein switches can detect analytes as components of inexpensive homogeneous assays that do not require specialized equipment or time-consuming incubation and washing steps characteristic of immunoassays [8]. Protein switches have also

• br Introduction Breast cancer is

  2023-12-18

  

  Introduction Breast cancer is the second most lethal cancer among women, accounting for approximately 40,000 deaths in the United States in 2015 [1]. The prognosis of breast cancer has improved significantly with the identification of immunohistochemical subtypes that predict response to therapy

• Overexpression of AR in a transgenic mouse model

  2023-12-16

  

  Overexpression of AR in a transgenic mouse model leads to a capsular cataract phenotype involving proliferation and formation of a fibrotic plaque of cells reminiscent of cells at the posterior Oxaliplatin in PCO [17]. To investigate the molecular mechanism that could link AR expression to this phen

• br Materials and methods br Results br Discussion

  2023-12-16

  

  Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi

• calcium channel blocker Notably our preliminary results conf

  2023-12-16

  

  Notably, our preliminary results confirmed that fluoxetine (SSRIs, 5–10 mg/kg) and duloxetine (SNRIs, 5–10 mg/kg) could not enhance memory function in the novel object recognition or step-down passive avoidance tasks (data not shown). In the present study, we also found that vilazodone showed had no

• Mitochondria from frozen thawed bull sperm are capable

  2023-12-16

  

  Mitochondria from frozen-thawed bull sperm are capable of producing energy using pyruvate and lactate as substrates through oxidative pathways (Beorlegui et al., 1997). Based on the present study, heparin capacitated sperm had a lesser lactate concentration in the incubation medium, supporting the h

• Although the effects of adenosine receptor signaling in acut

  2023-12-16

  

  Although the effects of adenosine receptor signaling in acute renal IRI have been attributed to the generation of high concentrations of adenosine, we have recently reported an increase in kidney levels of both AMP and adenosine, with a concomitant fall in ATP and ADP. We have also previously demons

• Control of retinal vascularization during

  2023-12-16

  

  Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial Tolvaptan (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a critical role in develop

• br Introduction ACK or Activated Cdc Associated Kinase locat

  2023-12-16

  

  Introduction ACK1, or Activated Cdc42-Associated Kinase, located on chromosome 3q, is a ubiquitously expressed non-receptor tyrosine kinase cloned from a human MK-4827 hydrochloride cDNA library (Manser et al., 1993). It was first identified to bind to activated Cdc42, a small Ras GTPase via its

• The results show that a tonic

  2023-12-16

  

  The results show that a tonic action of ACh on respiration is lacking. However, it is clear that muscarinic cholinergic mechanisms can modulate both eupneic breathing and the cough reflex. When these mechanisms are brought into action is obscure and only tentative proposals can be advanced. ACh in t

• Finally Urban Ciecko et al

  2023-12-16

  

  Finally, Urban-Ciecko et al. (2018) asked whether this enhancement is specific to the pyramidal to SST neuron synapses or more generally observed in other synapses of the cortical microcircuit. Synapses between pyramidal cells showed no sign of potentiation after either bath application of the choli

• br Autophagy and cell death pathways in ischemic stroke Alth

  2023-12-16

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Leupeptin injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morphol

• br Acknowledgment br Introduction The

  2023-12-16

  

  Acknowledgment Introduction The yeast Cdc48 ATPase and its metazoan ortholog p97 (or VCP) are critical components of many ubiquitin-dependent cellular pathways that require the segregation of individual proteins from binding partners or membranes (for review, see Buchberger, 2013, Meyer and We

• Suspecting that ACL might regulate the expression or activit

  2023-12-16

  

  Suspecting that ACL might regulate the expression or activity of myogenic transcription factors, Das knocked down MyoD and found that such intervention abolished the effect of ACL on fast MyHC expression and that, conversely, MyoD overexpression partially rescued reduced fast MyHC expression caused

• However most of these SBVS studies were focused on

  2023-12-16

  

  However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive

16541 records 231/1103 page Previous Next First page 上5页 231232233234235 下5页 Last page