• Historically increased tau phosphorylation has

  2018-11-09

  

  Historically, increased tau phosphorylation has been associated with neural demise. Consequently, rodent studies exploring increased neurofibrillary pathology after exposure to cooling-re-warming paradigms have linked this pathological risk with hypothermic hyperphosphorylation of tau (Planel et al.

• br Ethical approval br Conflict of interest br Acknowledgeme

  2018-11-08

  

  Ethical approval Conflict of interest Acknowledgements We thank the Australian Government\'s Cooperative Research Centre Program and the China Scholarship Council for financial support. We would also like to acknowledge the support of staff from the Postharvest Biosecurity and Food Safety L

• br Results br Discussion These results are in line

  2018-11-08

  

  Results Discussion These results are in line with the known strong immunosuppressive effects of extracellular adenosine accumulation, mediated mainly through ADORA2A adenosine receptors (Sitkovsky and Ohta, 2005), and with previous reports showing the role of adenosine production by Tregs in i

• br Results br Discussion In this study

  2018-11-08

  

  Results Discussion In this study, we identified altogether 21 novel imprinted DMRs, including a novel class of intergenic DMRs, which reside in regions with no apparent imprinted vorapaxar in PSCs. This class of imprinted DMRs either may regulate genes in a tissue-specific manner, thus adding

• In the present study we used

  2018-11-08

  

  In the present study, we used a piglet model of cerebral hypoxia–ischemia; a powerful in vivo model which emulates important clinical similarities to human situation of birth asphyxia, to evaluate the NSP cell proliferation, differentiation and neurogenesis in SVZ of newborn piglets subjected to PC

• br Introduction Breast cancer is a heterogeneous disease

  2018-11-08

  

  Introduction Breast cancer is a heterogeneous disease characterized by at least eighteen histopathological and six distinct molecular subtypes, making it extremely difficult to treat (Sørlie et al., 2001). This phenotypic diversity is considered to reflect the epithelial lineage from which a give

• In our study To determine a profile of gene

  2018-11-08

  

  To determine a profile of gene activation within the hearts of AMI rats following EXnaEFC administration, we performed a comprehensive PCR analysis of cardiac tissue seven days post-infarct and treatment. We reveal that the rats receiving EXnaEFCs exhibited rescued gene expression of Tnf, Sdf1 and C

• Paradoxically we found that mutant K Ras

  2018-11-08

  

  Paradoxically, we found that mutant K-Ras increases proliferation of quiescent intestinal stem Digoxigenin-11-ddUTP (Fig. 2), but also increases repair following damage (Fig. 3). This phenomenon is similar to the role that oncogenic N-Ras plays in hematopoietic stem cells (HSCs) (Li et al., 2013). I

• In contrast to chronic TLR activation and inflammation short

  2018-11-08

  

  In syk inhibitor to chronic TLR activation and inflammation, short time stimulation of the innate immune system may have completely different tasks with respect to tissue maturation and repair. It is well known that bone healing during fracture repair is induced by platelet derived growth factor st

• br Materials and methods br Author disclosure

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments This work was supported by the UK Medical Research Council grants G0701172 and G0801061. We thank Dr. Yacoub Khalaf, Director of the Assisted Conception Unit of Guy\'s and St Thomas\' NHS Foundation Trust and his staff for su

• Human ESC culture and processing

  2018-11-08

  

  Human ESC culture and processing were performed in a grade A tissue culture cabinet in a grade B clean room environment monitored for particulate and microbiological contamination during cell processing in accordance with Rules and Guidance for Pharmaceutical Manufacturers and Distributors — The Ora

• br Materials and methods br Acknowledgments This

  2018-11-08

  

  Materials and methods Acknowledgments This work was supported by grants from the National Basic Research Program of China (973 program 2011CB964901 and 2012CB944901), the National Natural Science Foundation of China (81101510 and 31101053), Natural Science Foundation of Hunan Province (14JJ200

• In this study we evaluated if different and distant

  2018-11-08

  

  In this study, we evaluated if different and distant anatomic regions of fat depots, albeit limited to the thoracic cavity, might reflect a heterogeneous array of biological, functional and ultrastructural features of ASCs. Our results support previous findings on putative differences between ASC po

• The generation of NPC patient specific induced pluripotent s

  2018-11-08

  

  The generation of NPC patient-specific induced pluripotent stem 7 8-dihydroxyflavone (iPSCs) provides access to unlimited numbers of disease-affected cell types and a unique opportunity to gain mechanistic insights and screening for new cell type-specific therapeutic compounds (Grskovic et al., 2011

• Gene expression analysis revealed that cells differentiated

  2018-11-08

  

  Gene expression analysis revealed that cells differentiated for up to 30 days expressed markers implicated in endoderm specification and TEC development but lacked the expression of important late-stage TEC markers associated with functional maturation. In particular, relative to human pediatric thy

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