• Besides our strongest GWAS signal we

  2018-11-14

  

  Besides our strongest GWAS signal, we also found association signals which have previously been associated with complex diseases including sepsis phenotypes. Genomic variation in CRISPLD2 was reported to be associated with the presence of cleft lips (Mijiti et al., 2015), and recent work showed a de

• To address these knowledge gaps in

  2018-11-14

  

  To address these knowledge gaps in the pathogenesis of TBI, we conducted a comprehensive systems biology study (Fig. 1) focusing on the impact of concussive injury on fundamental gene regulatory mechanisms. Unlike previous studies based on microarrays (von Gertten et al., 2005; Rojo et al., 2011; Sa

• Autophagy enables cancer cell survival

  2018-11-14

  

  Autophagy enables cancer cell survival by maintaining energy production, which can lead to therapeutic resistance (). Several preclinical studies showed that clinically relevant doses of radiation directly promote autophagy in cancer cells and inhibition of autophagy can restore chemosensitivity and

• Conflict of Interest br Non human primate NHP models

  2018-11-14

  

  Conflict of Interest Non-human primate (NHP) models utilizing infection with simian immunodeficiency viruses (SIV) remain the most compelling means to inform mechanisms of protection and viremic control as a guide to development of HIV vaccines for prevention and therapy short of human efficacy t

• Even if the DP of the

  2018-11-14

  

  Even if the DP of the method calculated from this study is >0.99 (DP=0.995, as compared to 0.992 in our previous study (Gits-Muselli et al., 2015)), the distance between P. jirovecii genotypes remains low using our MLP typing method, resulting in a limited number of genetic groups. This low genetic

• br Experimental design materials and

  2018-11-14

  

  Experimental design, materials and methods Acknowledgements Data Data refers to the LSCM and TEM experiments of 100% bio-sourced glycine betaine (GB) surfactant possessing a C18:1 oleic fatty chain and kappa-carrageenan under pure forms in aqueous solutions (Fig. 1) or after their mixing at

• br Experimental design materials and methods br Funding sour

  2018-11-14

  

  Experimental design, materials and methods Funding sources This work was supported by Paul Sabatier University (Toulouse, France), Région Midi-Pyrénées and by the French Ministry of Higher Education and Research. Acknowledgements Data The dataset contained in this article provides a det

• br Materials and methods br Results We measured and

  2018-11-13

  

  Materials and methods Results We measured and analyzed cABRs to the [da] syllable in 64 literate children and in 95 preliterate children. Fig. 1b shows the averaged cABRs across participants for the [da] syllable. Fig. 1c exemplifies individual brainstem responses of two single participants. O

• br Introduction Speech is an inherently variable signal toke

  2018-11-13

  

  Introduction Speech is an inherently variable signal: tokens of identical phonemes and words are acoustically distinct. When acquiring their native language, infants have thus to detect the equivalence of these different tokens in spite of their variability. For instance, the acoustic properties

• br Introduction Academic abilities like mathematical attainm

  2018-11-13

  

  Introduction Academic abilities, like mathematical attainment, are dependent on not only ability-specific training but also general cognitive skills. Mathematical performance is highly correlated with non-verbal reasoning abilities (Geary, 2011), working memory (WM) capacity (Gathercole et al., 2

• Thus the present work describes the out of plane distortion

  2018-11-13

  

  Thus, the present work describes the out-of-plane distortion generated in multi-pass full circumferential fillet welding of tube to pipe under different weld sequences and directions. The studies were carried out using FEM based Sysweld [13] software. Firstly, the thermal analysis of the FEM model f

• br Por estas razones la operaci n deber a

  2018-11-13

  

  Por estas razones, la operación debería ser postergada hasta tanto la menor adquiriera la capacidad para dar un consentimiento libre e informado. Línea jurisprudencial Basándome en la metodología propuesta por el profesor Diego López Medina (2000: 67 y ss.), se describen las orientaciones plas

• Narcolepsy is a term that comes from the French

  2018-11-13

  

  Narcolepsy is a term that comes from the French , coined in the 19th century by the French physician Gélineau from the combined form of the Greek words (“numbness”, “stupor”) and (“an attack”, “seizure”). Since its description, narcolepsy has gained increased attention, being a sleep disorder that

• The affinity binding of Os

  2018-11-13

  

  The affinity binding of Os(bpy)2(DPPZ)++ with PCR product was measured by the Scatchard plot (data not showed) [19]. A Kb value of 1.5×106M−1 was found. This is in agreement with both the Kb=4×106M−1 determined for calf thymus DNA and Kb=5×106M−1 determined for PCR product [12]. To finally demonstr

• br Acknowledgements This work was partly

  2018-11-13

  

  Acknowledgements This work was partly supported by the Center of Innovation Program from Japan Science and Technology Agency, JST, and was also partly supported by the Research Institute for Science and Engineering, Waseda University (14P56). Introduction Alpha fetoprotein (AFP), a glycoprote

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