• prostaglandin endoperoxide synthase As with many biological

  2018-11-12

  

  As with many biological phenomena, immunomodulation is a double-edged sword, and many of these tolerogenic mechanisms appear to be manipulated by cancer prostaglandin endoperoxide synthase to create an immunoprivileged niche to further their own growth (Rabinovich et al., 2007). One of the most pro

• Several transcripts that exhibited an expression change trig

  2018-11-12

  

  Several transcripts that exhibited an expression change triggered by T3 are promising candidates for being responsible for the observed increased cell extension growth of ENS cells in vitro. The calcium dependent cell adhesion molecule cadherin 12 (Cdh12, N-cadherin, 5.6 fold upregulated), the gene

• An alternative approach would be to identify

  2018-11-12

  

  An alternative approach would be to identify successful examples of organ regeneration in nature, dissect their mechanisms, and then attempt to apply gained insights to humans via the provision of the appropriate regenerative stimuli. Urodele amphibians and teleosts are well-known examples of animal

• Both natural and synthetic approaches have been used

  2018-11-09

  

  Both natural and synthetic approaches have been used to generate fully defined hPSC culture substrates. ECM proteins such as vitronectin and laminins 511 and 521 have been shown to maintain hESC pluripotency and self-renewal (Braam et al., 2008; Domogatskaya et al., 2012; Miyazaki et al., 2012; Rodi

• Introduction The correct functioning of the epigenome ensure

  2018-11-09

  

  Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-09

  

  Experimental Procedures Author Contributions Acknowledgments The targeted Ainv15 mESC line with was a kind gift from Paul Gadue (University of Pennsylvania). We would like to thank Brian R. Tilton and Patrick Autissier from the BU Flow Cytometry Core Facility as well as Michael T. Kirber fr

• Main Text In this issue of

  2018-11-09

  

  Main Text In this issue of Stem Cell Reports, two critically important studies describe negative results of a neural stem cell (NSC) product (HuCNS-SC) intended for clinical use in a model of cervical spinal cord injury (SCI) (Anderson et al., 2017) and in a model of Alzheimer’s disease (Marsh et a

• br Introduction Myelination of the

  2018-11-09

  

  Introduction Myelination of the CNS of mice occurs mainly within the first 4 post-natal weeks when oligodendrocyte progenitor cells (OPCs) differentiate into myelin-forming oligodendrocytes. After this period, adult OPCs of divergent developmental origins remain scattered throughout the CNS paren

• This approximation is ensured by the uniform convergence of

  2018-11-09

  

  This approximation is ensured by the uniform convergence of the flat series. The uniform convergence is proved in [3,4]. Similar function series (splitting expansions) are described in [5]; the concept of using the expansion in the form that it S63845 is done in this paper comes from Schwartz and H

• HZ-1157 The shape and the location of this

  2018-11-09

  

  The shape and the location of this peak were examined, and the parameters necessary for constructing the Fano profile (6) were computed (see Table 2). The computed peak location is in good agreement with the experiment; unfortunately, however, since it is narrow and highly intense, no specific conc

• The possibility of observing a new type

  2018-11-09

  

  The possibility of observing a new type of quantum transport in an inelastic channel was predicted on the assumption that the motion of electrons occurs in such a manner that in addition to inelastic scattering, the electrons experience single scattering through a large angle. Later it was revealed

• A further test of the second experimental

  2018-11-09

  

  A further test of the second experimental setup was carried out, and the results are shown in Figs. 17–19, where the distances from point A and point B to the geophone are 32 m and 31.5 m, respectively, the angle of DOA equals to 45° with respect to the axis of NS and EW. A buried stone happened to

• Although it is clear that smoking

  2018-11-09

  

  Although it d-cycloserine is clear that smoking cessation reduces cancer risk (Jha et al., 2013), and that CHRNA5 risk variants affect both smoking heaviness and duration, it is unclear whether CHRNA5 alters the health benefits of smoking cessation. For example, the CHRNA5 high-risk variants may di

• However one might question whether effective compounds that

  2018-11-09

  

  However, one might question whether effective compounds that do not bind to the C-terminal domain of PrP or that have other molecular targets besides PrP () will be excluded from this virtual screening. In the first case, docking with at least the 90–231 domain of the prion protein will prove useful

• The clinical heterogeneity in AOS patients makes

  2018-11-09

  

  The clinical heterogeneity in AOS patients makes it difficult to study SMAD3 mutational effects on aneurysm formation. Fortunately, due to the homogenous genetic background, genetically engineered mouse models are useful in pinpointing the specific molecular mechanism leading to disease. Smad3 knock

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