• Introduction Osteosarcoma OS is the most commonly

  2019-04-19

  

  Introduction Osteosarcoma (OS) is the most commonly diagnosed histological form of primary bone tumor with high morbidity, and it is mainly prevalent in teenagers and young people [1]. Pain is the most common early symptom of OS and can cause fracture of the affected bone. Currently, multiple thera

• br Results br Discussion br Conclusions br

  2019-04-19

  

  Results Discussion Conclusions Disclosures Conflict of interest Financial support Introduction Stroke is one of the top five common causes of mortality in Malaysia with a rate at 8.43/100,000 cdc42 inhibitor [1,2]. Stroke impact is not limited to physical disabilities that stro

• Any abnormality causing a loss of function in

  2019-04-19

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• Common and rare SCN A variants may contribute to AF

  2019-04-19

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• Si se rescata de estas

  2019-04-19

  

  Si se rescata de estas afirmaciones, en primer término, la pretensión crítica realista como fundamento de su propuesta literaria, algunos de los cambios en su entorno cultural cobran relevancia para contextualizar su interés por la ironización de la realidad dentro de la heterogeneidad de su obra. C

• 5-Iodotubercidin In their analysis the investigators did not

  2019-04-19

  

  In their analysis, the investigators did not include common causes of CKD in sub-Saharan Africa other than HIV, diabetes, and hypertension—notable omissions were chronic glomerulonephritis and use of herbal or traditional treatments. Also, communicable diseases might contribute substantially to CKD

• Although the long term stability of childhood

  2019-04-19

  

  Although the long-term stability of childhood intelligence during the life course has been shown in longitudinal studies, studies of the long-term effects of breastfeeding are important. With age, the effects of early developmental factors might either be diluted, because of the effects of later env

• Tambi n los miembros del

  2019-04-18

  

  También los miembros del mocase consideran que la cooptación es una estrategia permanente del gobierno, al señalar como ejemplo de ello la creación de espacios como la llamada “Mesa del Diálogo por la Tierra” o el Programa del Campo, calificados como “instrumentos para la cooptación de varias organi

• One year after her initial diagnosis

  2019-04-18

  

  One year after her initial diagnosis, the patient presented back for the abrupt onset of symmetrical bilateral lower-limb weakness and numbness. The patient did not report other symptoms or history of trauma. Clinical examination revealed a healthy person except for a symmetrical proximal and distal

• br Prior to Zika virus

  2019-04-18

  

  Prior to 2013–14, Zika virus infection was described as a mild febrile illness with clinical symptoms. However, the emergence of Zika virus in the Pacific and the Americas, the sharp increase in cases of Guillain-Barré syndrome (GBS), and the birth of babies with neurological complications such as

• br Conflict of interest br Introduction Far field sensing of

  2019-04-18

  

  Conflict of interest Introduction Far-field sensing of the atrial electrogram by a ventricular inhibited (VVI) pacemaker is a rare but potentially catastrophic phenomenon if there is no escape rhythm [1–3]. In this setting, the tip of the pacemaker lead is usually located in close proximity to

• br Discussion Studies have reported

  2019-04-18

  

  3. Discussion Studies have reported that permanent PMI using the conventional pectoral approach is impossible or contraindicated in 1–6% of patients [1–5]. In such patients, PMI via the iliac vein is considered an effective alternative. The advantages of this approach are that the wound size and

• br Material and methods The study subjects were

  2019-04-18

  

  Material and methods The study subjects were 28 consecutive patients with organic purchase TASIN-1 disease who underwent ICD implantation for the secondary prevention of sudden cardiac death, based on the indications for ICD implantation in the European Society of Cardiology׳s guidelines [12]. T

• br Conflict of interest br Authors contributions br Acknowle

  2019-04-17

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• T wave was similar in seven patients The terminal portion

  2019-04-17

  

  T-wave was similar in seven patients. The terminal portion of the T-wave was negatively inverted compared with that at baseline in five patients on using ER-2000®. Representative example of sinus rhythm with T-wave discordance is shown in online Supplementary Fig. S3. T-wave morphology was different

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